Rob Morrow扮演的FBI探员和他那具备超乎常人数学天才的弟弟Charlie一起侦破了在L.A发生的大范围严重罪案。Charlie对案件独特的思考方式让Don的同僚Terry Lake 和David Sinclair 都感到十分惊讶。与此同时，Don和Charlie的父亲对于两个儿子专注执着的个性会否使彼此在工作中产生摩擦感到担心。Larry Fleinhardt 是Charlie的学院导师，他希望Charlie专注于学术研究而不是浪费无谓的精力帮助警方破案。
NUMB3RS将会通过真实的事例，反映数学理论是如何被应用到警方的调查之中，从而破解一件件匪夷所思的罪案。
“In the early 1990s, at the height of the international war on drugs, the government agency in charge of Britain’s borders, Her Majesty’s Customs and Excise, realized that they were losing the battle against drug smuggling. Their solution was extraordinary,” reads the logline. “In a top-secret operation, a small team of British Customs employees were sent undercover. Their task – to infiltrate Britain’s most dangerous drug gangs.” “They were not trained spies. These were ordinary men and women, plucked from ordinary lives around the U.K, put through a basic training regime then told to build new identities in the criminal underworld. These identities were called Legends.
改编自维克托·拉瓦列2013年的小说《The Devil in Silver》。聚焦搬运工人Pepper（丹·史蒂文斯 Dan Stevens 饰），因为坏运气和坏脾气，他被送到了一所名为New Hyde的精神病院，里面满是被社会遗忘的人。Pepper想要获得自由，就必须面对与他作 对的病人、怀着阴森目的的医生，甚至恶魔本人。这里是地狱般的地方，任何事情都不是表面那样，Pepper必须直接面对一个以New Hyde里人们的苦痛来蓬勃壮大的存在，但这样可能会证明：最可怕的恶魔恰恰是他自己。
