终于有一天,人类向日渐增多的血族和狼族宣战,这两个族群遭到大肆围剿与屠杀,人类取得绝对的优势。塞琳娜(凯特·贝金赛尔 Kate Beckinsale 饰)和约翰也在这场浩劫中遭难,当她再次醒来时,却发现自己被名为抗原研究所的机构囚禁起来,编号实验品1号。她奋力突破了束缚,根据共视的能力在黑暗的都市中寻找实验品2号——约翰。途中她遭遇血族的同伴相助以及狼人的袭击,当她找到被狼人们追逐的实验品2号时却发现,眼前竟是一个从没见过面但有着极为恐怖力量的小女孩——伊薇(英迪娅·埃斯利 India Eisley 饰),而她是血族与狼族的混血儿。
在这个陌生的时代,塞琳娜注定继续过着血雨腥风的生活……
Young couple Madeleine and Neil are coaxed by acquaintance Monsieur Beaumont to get married on his Haitian plantation. Beaumont's motives are purely selfish as he makes every attempt to convince the beautiful young girl to run away with him. For help Beaumont turns to the devious Legendre, a man who runs his mill by mind controlling people he has turned into zombies. After Beaumont uses Legendre's zombie potion on Madeleine, he is dissatisfied with her emotionless being and wants her to be changed back. Legendre has no intention of doing this and he drugs Beaumont as well to add to his zombie collection. Meanwhile, grieving 'widower' Neil is convinced by a local priest that Madeleine may still be alive and he seeks her out.